Analysis of acute radiation injury in non-small cell lung cancer treated by three-dimensional conformal radiotherapy
10.3760/cma.j.issn.0254-5098.2010.03.024
- VernacularTitle:非小细胞肺癌三维适形放射治疗后急性放射性肺损伤分析
- Author:
Yanli CUI
;
Shuchai ZHU
;
Zhikun LIU
;
Jingwei SU
;
Juan LI
;
Wenbin SHEN
;
Yuxiang WANG
- Publication Type:Journal Article
- Keywords:
Non-small cell lung cancer;
Three dimensional conformal radiotherapy;
Radiation induced injury;
Dose-volume histogram(DVH)
- From:
Chinese Journal of Radiological Medicine and Protection
2010;30(3):320-323
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the influencing factors with radiation induced injury of nonsmall cell lung cancer(NSCLC)treated by three-dimensional conformal radiotherapy,in order to supply he reference criteria for optimize the treatment planning of NSCLC, further to improve the local control rate and quality of life of NSCLC patitents.Method From Aug 2000 to Dec 2004,107 NSCLC patients received three-dimensional conformal radiotherapy were enrolled in this study.In all the patients,48 patients accepted three dimensional conformal radiotherapy(3D-CRT),the other 59 patients accepted conventional radiotherapy(CRT)before later-course of 3D-CRT.All of the patients received the prescription dose between 60-78 Gy and the median dose 66 Gy.Results In the 107 patients,the rate of radiation induced injury was 62.6%.and the rate of≥2 grade was 38.3%.23 cases were classified in grade 2,14 cases in grade 3,4 cases in grade 4.Univariate analysis showed chronic obstructive pulmonary disease,number of beams field,lung mean dose,lung V5-V40 were important influencing factors on radiation induced injury.Further more,lung mean dose,lung V20 and chronic obstructive lung disease were likely to be the independent factors of radiation induced injury by Logistic model.Conclusions lung mean dose,chronic obstructive lung disease and lung V20 were the independent influencing factors on irradiated induced injury.
