Intervention of Astragalus membranaceus on radioactive lung injuries and influence on TNF-α and ET expression
10.3760/cma.j.issn.0254-5098.2010.03.026
- VernacularTitle:黄芪对放射性肺损伤干预作用及对肿瘤坏死因子-α和内皮素表达影响的研究
- Author:
Lei XI
;
Dehong XIA
;
Weisheng SHEN
;
Jianbo ZHOU
;
Zhongqin SHU
;
Bo YU
;
Xinheng HOU
;
Ke WANG
- Publication Type:Journal Article
- Keywords:
Radiotherapy;
Astragalus membranaceus;
Lung injuries;
Radioprotection;
TNF-α;
Endothelin
- From:
Chinese Journal of Radiological Medicine and Protection
2010;30(3):327-329
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the lung protection of Astragalus membranaceus against radiotherapy to intermediate-stage and terminal thoracic neoplasm, and its influence on TNF-α and ET expression.Methods The patients with intermediate-stage and terminal thoracic neoplasm under radiotherapy were divided into a treatment group and a control group.Patients in the treatment group took 10 ml of Asragalus membranaceus twice a day.for consecutive 6 months from the beginning of radio therapy.TNF-α and ET in the plasma were measured before and after the radiotherapy.The clinical symptom,iconographic changes and lung diffusion were observed from the 15th day of radiotherapy.Results The TNF-α and ET in plasma afterthe radiotherapy were(2.48±0.75)as/ml and(69.32±23.03)pg/ml for the treatment group,and(5.12±1.01)ns/ml and(97.87±37.83)pg/ml for the control group with the statistial difference(x2=7.49,6.57,P<0.001).The decrease of CO diffusion 5 and 10 months after the radiotherapy in the treatment group was statistically different compared with that in the control group(x2=3.98,3.78,P<0.05).There was a statistical difference of the incidence of acute radiation pneumonitis and pulmonary fibrosis between these two groups(P<0.05).Conclusions Astragalus membranaceus could inhibit the excess expression of TNF-α and ET in plasma and reduce the deterioration of diffusion after radiotherapy,so that it can be used for intervention of lung injuries from radiotherapy.
