Effects of C4d deposition in peritubular capillary of patients with acute renal allograft rejection one year post-transplant on the prognosis of renal allograft
10.3760/cma.j.issn.0254-1785.2010.06.004
- VernacularTitle:肾移植一年后急性排斥反应时移植肾组织中C4d表达阳性的临床研究
- Author:
Ming CAI
;
Liang XU
;
Xiaoguang XU
;
Qiang WANG
;
Zhouli LI
;
Yong HAN
;
Bingyi SHI
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Graft rejection;
Complement C4
- From:
Chinese Journal of Organ Transplantation
2010;31(6):332-335
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze C4d deposition in the patients with late acute renal allograft rejection,and explore the role of C4d in grafts survival and grafts loss. Methods Thirty-six patients clinical and pathologically diagnosed as having acute rejection more than one year post-transplant were selected. C4d was detected by immunohistochemistry in renal allograft biopsies. The effect of C4d deposition on long-term graft survival was studied. Results Among 36 recipients with late acute renal allograft rejection, 16 cases were positive for C4d (44.4 %) and 20 negative for C4d (55.6 %). Five cases experienced graft loss in C4d positive group (31.3 %), while 6 cases in C4d negative group (30.0%). There was no significant difference in the graft loss rate between C4d-positive group and C4d-negative group. Log-Rank test demonstrated there was no significant difference in graft survival between C4d-positive group and C4d-negative group. The count of the interstitial infiltrated eosinophils in renal allograft was (9.4 + 4.5) and (2.6 + 1.8) respectively in the C4d-positive group and C4dnegative group (P＜0.05). Conclusion C4d deposition in peritubular capillary of the recipients with late acute renal allograft rejection might not be a prognostic marker for graft outcome.
