Protective roles of neuregulin-1 in cerebral ischemia
10.3760/cma.j.issn.1673-4165.2010.005.009
- VernacularTitle:神经调节蛋白-1在脑缺血中的保护作用
- Author:
Lili ZANG
;
Yuzheng DU
;
Zhibo GUO
;
Qin CHU
- Publication Type:Journal Article
- Keywords:
Neuregulin-1;
Brain ischemia;
Neuroprotective agents;
Inflammation;
Apoptosis
- From:
International Journal of Cerebrovascular Diseases
2010;18(5):363-367
- CountryChina
- Language:Chinese
-
Abstract:
Neuregulin-1,a member of the epidermal growth factor family,plays an important role in the neuronal survival,development,migration,myelin formation,and synaptic plasticity and function. This article mainly summarized the structure and function of neuregulin1 and its neuroprotective roles in cerebral ischemia. Tne neuroprotective mechanisms of neuregulin-1 may include the inhibition of the early inflammatory response and apoptosis,and the regulation of the expression the neurotrophic factors.
