Cerebral ischemic postconditioning and its neuroprotective mechanisms
10.3760/cma.j.issn.1673-4165.2010.005.010
- VernacularTitle:脑缺血后处理及其神经保护机制
- Author:
Chengping BAI
;
Lixuan ZHAN
;
En XU
- Publication Type:Journal Article
- Keywords:
Brain ischemia;
Brain infarction;
Reperfusion;
Neuroprotective agents;
Inflammation;
Apoptosis;
Oxidative stress;
Protein kinases
- From:
International Journal of Cerebrovascular Diseases
2010;18(5):368-372
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral ischemic postconditioning (IPO) refers to a series of rapid intermittent interruptions of blood flow in the early phase of reperfusion. It protects brain tissue against ischemia-reperfusion injury. IPO decreases infarct volume and neuron loss by activating protein kinases,blocking apoptosis pathways,inhibiting inflammation and oxidative stress. IPO can be applied after cerebral ischemia,and it has better application prospects in clinical practice. This article reviews IPO and its neuroprotective mechanisms.
