Effects of intensive insulin therapy on IL-10 level and NF-ΚB activity in patients undergoing cardiopulmonary bypass
10.3760/cma.j.issn.1008-6706.2010.11.018
- VernacularTitle:胰岛素强化治疗对体外循环术后外周血IL-10浓度及单核细胞核因子-κB活性的影响
- Author:
Wendong YANG
;
Wei WEI
;
Dong HUANG
;
Biao ZHONG
- Publication Type:Journal Article
- Keywords:
Cardiopulmonary bypass;
Blood glucose;
Insulin;
Interleukin-10;
Nuclear factor-κB
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(11):1478-1480
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of intensive insulin therapy on IL-10 level and NF-ΚB activity in peripheral blood mononuclear cells in patients undergoing cardiopulmonary bypass.Methods The non-diabetic patients undergoing cardiopulmonary bypass in our department were selected and assigned to intensive therapy group (group A,n=40) and received strict glycemic control after the initiation of surgery.And those who undergoing cardiac surgery but without strict glycemic control were assigned to routine therapy group (group B,n=40) as controls.The blood glucose in group A was maintained at 4.4～8.3mmol/L,whereas the glucose in group B was below 11.lmmol/L.The concentration of serum IL-10 and NF-ΚB activity in peripheral blood mononuclear cells was measured at different time points.Results There were no significant differences in general data between two groups.The concentration of IL-10 in group B was significantly lower than that in group A(P<0.05).compared with group B,strict glycemic control markedly suppressed NF-KB activation (P<0.05).Conclusion Intensive insulin therapy could reduce the activity of NF-ΚB and then reduce the expression of IL-10.Strict glycemic control could significantly mitigate the systemic inflammatory response.
