Study on correlation of mammographic features、pathology and molecular bology of breast infiltrating ductal carcinoma
10.3760/cma.j.issn.1008-6706.2010.12.005
- VernacularTitle:乳腺浸润性导管癌X线表现、病理与分子生物学标记关系的研究
- Author:
Qiyuan ZOU
;
Wubin HUANG
;
Weihong QIU
;
Kangfeng PAN
;
Hongyan HE
;
Xiaochao FANG
;
Xiangxiang CHEN
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Mammography;
Pathology;
Molecular biology
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(12):1594-1596
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation among mammographic features、pathology and molecu-lar biology markers of breast infitrating ductal carcinoma(IDC) tissues.Methods The mammographic features of 93 cases with IDC confirmed by surgery and histopathology were analyzed retrospectively.The mastectomy specimens of the IDC were stained with immunohistochemistry,and the expression of ER、PR、C-erbB-2 were measured.The rela-tionship between the immunohistochemical pathologic results and mammographic features was analyzed.Results A-mong the 93 cases of IDC,ER positive expression was positively correlated with the spiculate margin of breast cancer (P<0.05);C-erbB-2 positive expression was positively correlated(P<0.05).Moreover,ER and PR positive expres-sion showed a significant inverse correlation with the calcifying of breast cancer(P>0.05);ER and PR positive ex-pression was positively correlated with the transfer of lymph(P<0.05);there existed correlation between the positive expression of C-erbB-2 and lymphatic metastasis and pathohistology grade(P<0.05).Conclusion There was a pos-itive correlation among IDC mammography、pathology and the abnormal value of ER、PR and C-erbB-2.The X-ray mammography could reflect the diagnosis value of ER、PR and C-erbB-2 roughly,and thadpractical value in determi-ning prognoses and endocrinotherapy.
