The changes and significance of plasma B-type natriuretic peptide in type 2 diabetes mellitus patients with heart failure

VernacularTitle:2型糖尿病合并心力衰竭患者血浆B型钠尿肽的变化及意义
Author: Lina GUO
Publication Type:Journal Article
Keywords: B-type natriuretic peptide; Diabetes mellitus; Heart failure
From: Chinese Journal of Primary Medicine and Pharmacy 2010;17(11):1456-1457
CountryChina
Language:Chinese
Abstract: Objective To study the relationship between B-type natriuretic peptide(BNP) and type 2 diabetes mellitus(DM) patients with congestive heart failure(CHF).Methods 78 patients with DM were divided into pure DM group(n=37) and DM+CHF group(n=41) ,the level of plasma BNP in patients with DM(n=78) and normal control group(n=20) was.measured.Results The level of plasma BNP in grade Ⅱ ,Ⅲ～Ⅳgroup of cardiac function were significantly higher than that in pure DM group and control group(P<0.05),grade Ⅲ～Ⅳ group were significantly higher than that in grade II group(P<0.05),LVEF in Ⅱ,Ⅲ～Ⅳgroup of cardiac function were significantly lower than that in pure DM group and control group(P<0.05),grade Ⅲ～Ⅳ group were significantly lower than that in grade Ⅱ group(P<0.05) ;The level of plasma BNP was positively related to LVEF(r= -0.713,P<0.05).Conclusion BNP was an objective indicator to evaluate the severity of DM with heart failure.