Effect of IL-6 and TNF-a in the Cervical Spondylotic Myelopathy

VernacularTitle:白介素6、肿瘤坏死因子α在脊髓型颈椎病发病中的作用
Author: Zijin LIU
Publication Type:Journal Article
Keywords: Cervical spondylotic myelopathy; IL-6; TNF-a
From: Chinese Journal of Primary Medicine and Pharmacy 2010;17(11):1464-1465
CountryChina
Language:Chinese
Abstract: Objective To measure the levels of interleukin-6 (IL-6) and tumor necrosis factor-a( TNF-a) in the cervical intervertebral disk of patients with cervical spondylotic myelopathy ( CSM) ,study the role of IL-6 and TNF-a in the pathogenesis of CSM.Methods 40 degenerative cervical vertebral disk tissues were collected from CSM cases;20 normal tissues of vertebral disk were taken as control.The contents of IL-6 and TNF-a were detected by ELISA.Results The contents of IL-6 and TNF-a in disk of CSM sufferers increased significantly compared with the control group (P<0.01).Conclusion The results of the present study indicated that IL-6 and TNF-a may be involved in the pathogenesis of CSM.