Effects of different anesthesia methods on immune function of patients with biliary tract surgery
10.3760/cma.j.issn.1008-6706.2010.11.016
- VernacularTitle:不同麻醉方法对胆道手术患者免疫功能的影响
- Author:
Haipeng YUAN
- Publication Type:Journal Article
- Keywords:
Anesthesia,epidural,general;
T lymphocytes;
Natural killer cell
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(11):1474-1475
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of different anesthesia methods on immune function of patients with biliary tract surgery in patients.Methods 64 patients with ASA Ⅰ～Ⅱ grade elective biliary tract surgery were randomly divided into general anesthesia group (n= 32) and epidural anesthesia group(n = 32) respectively.The changes of T cell subsets and natural killer(NK) cells were observed.Results The levels of CD3+ 、CD4+、 CD4+、CD8+ and NK cells after anesthesia 2h,postoperation 1d and 3d were significantly lower than those before anesthesia in two groups(P<0.05) .general anesthesia group after surgery 5d were significantly lower than those before anesthesia(P<0.05) ;After surgery 1d,3d and 5d,general anesthesia group was significantly lower than epidural anesthesia group (P<0.05) ;The levels of CD3+、CD4+ in general anesthesia group was significantly lower than epidural anesthesia group(P<0.05) ,after surgery 1 d,the levels of CD4+、 CD8+ and NK cells in epidural anesthesia group were significantly lower than those in general anesthesia group(P<0.05).Conclusion Anesthesia had an inhibition of transient varying degrees for the immune function of patients uaderwent biliary tract surgery,which general anesthesia was more evident than epidural anesthesia.
