Fasting plasma obestatin levels in patients with different glucose tolerance and its association with lipid metabolism
10.3760/cma.j.issn.0254-9026.2010.06.011
- VernacularTitle:不同糖耐量状态下空腹血浆肥胖抑制素水平及其与脂代谢的相关性
- Author:
Pengying GU
;
Dongmei KANG
;
Yuan XIA
;
Hui ZHENG
;
Weidong WANG
;
Jian ZHOU
;
Cuiping ZHAO
;
Yan CHEN
- Publication Type:Journal Article
- Keywords:
Obestatin;
Diabetes mellitus,type 2;
Triglyeridees;
Cholesterol,LDL
- From:
Chinese Journal of Geriatrics
2010;29(6):480-482
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether fasting obestatin level is different in patients with impaired glucose tolerance or type 2 diabetes, and to explore the association between obestatin and lipid metabolism. Methods Eighty-four subjects without known diabetes were divided into three groups: normal glucose tolerance(NGT), impaired glucose tolerance (IGT) and type 2 diabetes (DM) Plasma obestatin levels were measured with a radioimmunoassay. The relationship between fasting obestatin levels and metabolic parameters was also analyzed. Results Fasting obestatin levels were lower in DM group [(2.82±0.78)ng/ml] and IGT group [(3.25±0.29)ng/ml] than in NGT group[(3.55±0.57) ng/ml, P＜0.01]. Triglycerides and low density lipoprotein cholesterol levels gradually increased among the three groups (P＜0.05). Multiple linear regression analysis revealed fasting obestatin level was independently associated with waist-to-hip ratio, triglyeride and low density lipoprotein cholesterol. The regression equation was obestatin=6.953-3.412×W/H-0.175×TG-0.123×LDL-C. Conclusions The decreased obestatin may be associated with IGR and T2DM, and obestatin level may be associated with lipid metabolism.
