Hyperbaric oxygen preconditioning ameliorates high positive acceleration exposure-induced impairment of learning and memory in rats
10.3760/cma.j.issn.1674-6554.2010.06.008
- VernacularTitle:高压氧预处理对高加速度暴露大鼠学习和记忆的影响
- Author:
Shufang FENG
;
Ye PENG
;
Qiang WANG
;
Lize XIONG
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
High positive acceleration;
Congnition;
Morris water maze
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2010;19(6):501-503
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of hyperbaric oxygen (HBO) preconditioning on learning and memory damage induced by high positive acceleration( + Gz) exposure in rats.Methods Thirty-two male Sprague-Dawley rats were randomly divided into four groups with 8 in each group: control group( Con), + Gz group,HBO group and HBO-+ Gz group.Rats of Con group were given 5d( 1 ATA ,21% O2, 1h/d); Rats of + Gz group was exposed to + 10Gz for 5 min; HBO group were only given 5d (2.5 ATA, 100% O2,1 h/d); HBO-+ Gz group were given HBO 5 consecutive days,and then suffered +Gz exposure.Morris water maze was used to observe the navigation and probe capabilities of rats.Results In the spatial acquisition test,there exist significant difference among these groups(F(3.28) = 5.325, P＜ 0.01 ).Compared with the control group, the escape latency increased significantly in the + Gz group and HBO-+ Gz group (P＜0.05) while had no difference in HBO group.HBO-+ Gz group had significantly shorter escape latency than + Gz group (P＜0.05).In the probe test,compared with the control group, + Gz group and HBO-+ Gz group had a longer percentage in the target quadrant( (43.71 ± 3.29 ) %vs (28.65 ±1.00)%, P＜0.05;(43.71 ±3.29)% vs (37.17 ±0.98)%, P＜0.05)),and HBO-+Gz group was better than + Gz group.Conclusion HBO preconditioning may have a protective effect on the impairment of learning and memory caused by + Gz exposure in rats.
