Long-term clinical outcome of combined therapy for nasopharyngeal carcinoma with cervical lymph node metastasis
10.3760/cma.j.issn.1004-4221.2010.04.003
- VernacularTitle:鼻咽癌颈部淋巴结转移综合治疗的远期疗效观察
- Author:
Rensheng WANG
;
Bo WEI
;
Min KANG
;
Yong ZHANG
;
Jinhua LEI
- Publication Type:Journal Article
- Keywords:
Nasopharyngeal neoplasms,lymph node metastasis;
Chemoradiotherapy;
Hyperthermia;
Long-term effect
- From:
Chinese Journal of Radiation Oncology
2010;19(4):289-291
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate long-term efficacy of microwave hyperthermia combined with chemoradiotherapy for nasopharyngeal carcinoma (NPC) with cervical lymph node metastasis. Methods A total of 154 patients with stage N2 or N3 NPC ('92 staging system) were randomized into two groups:microwave hyperthermia combined with chemoradiotherapy (Group A, 76 cases) and chemoradiotherapy alone (Group B, 78 cases). Both of the two groups received 1 -2 cycles of chemotherapy of cisplatin and 5-fluorouracil, followed by conventional radiotherapy of 70 - 78 Gy in 35 - 39 fraction to the nasopharynx and 68 -72 Gy in 34 - 36 fractions to the neck. Group A received microwave hyperthermia to the metastatic cervical nodes at the beginning of radiotherapy. The hyperthermia was given as 45 min every time, twice a week for 8 - 14 times totally. Results The 5-year complete response rates of cervical lymph nodes in group A and B were 97% and 77% (x2 = 14. 24,P<0. 01). The distant metastasis rates in the two groups were 37% and 44% (x2 = 0. 73, P > 0. 05). The disease-free survival rates were 51% and 21% (x2 = 15.91, P <0. 01). The 5-year overall survival rates were 59% and 41%, respectively (x2 = 5.09, P < 0. 05).Conclusions For patients with stage N2 or N3 NPC, microwave hyperthermia combined with chemoradiotherapy can improve the complete response, disease-free survival and overall survival.
