Explore the mechanisms of traditional Chinese medicine internal and external treatment on chronic osteomyelitis

VernacularTitle:中药内服外敷对慢性骨髓炎新生血管的调控机制的探讨
Author: Zhenyun LIU ; Yansheng CHEN ; Shaoqiu SUN ; Litian PENG ; Hengya TAN
Publication Type:Journal Article
Keywords: Osteomyelitis/PA/ZD; EXTERNAL APPLICATIONS ( TCD ); Neovascularization,physiologic
From: Journal of Chinese Physician 2010;12(6):765-767
CountryChina
Language:Chinese
Abstract: Objective To observe the effect of traditional Chinese medicine internal and external treatment on chronic osteomyelitis.Method Chronic osteomyelitis experimental animal models were set up with debridement, then it was random divided into two groups ( antibiotics group for the control group, antibiotics and traditional Chinese medicine group for the observation group).After treatment for 10 days, new capillaries in the tissues surrounding sinus crossings were detected by pathological observation and VEGF expression was determined by ELISA.Result VEGF expression and vascular points of tissues surrounding sinus crossings of antibiotics with traditional Chinese medicine group were obviously higher than that of antibiotics group[ (47.48 ±3.22) μg/ml vs (28.26 ±2.61)μg/ml, P ＜0.01;8.03 ±1.73 vs5.17 ±2.89, P＜0.05 ].Conclusion Traditional Chinese medicine internal and external treatment can improve VEGF expression and increase capillary number inside tissues surrounding sinus.crossings , thus it can promote the healing of chronic osteomyelitis.