Analysis of liver damage in AIDS/HIV patients coinfected by hepatitis virus
10.3760/cma.j.issn.1008-6706.2010.11.015
- VernacularTitle:艾滋病病毒重叠肝炎病毒感染患者肝功能受损分析
- Author:
Jinhua HUANG
- Publication Type:Journal Article
- Keywords:
AIDS virus,hepatitis virus;
Infection;
Liver function
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(11):1472-1473
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the damage of liver function in the AIDS/HIV patients with overlapping infection by hepatitis B virus (HBV) and hepatitis C virus (HCV).Methods 134 hospitalized cases with HIV-positive were tested for HBV and HCV infection by detecting serum markers.According to the testing results,the patients were divided into four groups including HIV + HCV group,HIV + HBV group ,HIV + HCV + HBV group,single HIV infected group as a control.Retrospective analysis was conducted on liver function among these four groups of patients.Results The most common type was HIV + HCV coinfection accounting for 74%.The median value of ALT in the control group was 26 U/L (16.25～37) ,while in the HIV + HBV,HIV + HCV,HIV + HBV + HCV groups it was 77(23～96) ,43(23～75.5) ,54(33.5～108) U/L,respectively.The control group was significantly different to overlapping infection groups (P<0.05).The median value of prothrombin time (PT) in HIV + HBV + HCV group is 14.6s( 12.9～15.2),significantly higher than the other three groups (P<0.05).Conclusion HCV overlapping infection was most frequent in HIV patients.liver function damage could be worsen in such patients especially in those with HBV and HCV positive simultaneously.
