Rifampicin-Induced Minimal Change Disease Is Improved after Cessation of Rifampicin without Steroid Therapy.
10.3349/ymj.2015.56.2.582
- Author:
Dong Hyuk PARK
1
;
Sul A LEE
;
Hyeon Joo JEONG
;
Tae Hyun YOO
;
Shin Wook KANG
;
Hyung Jung OH
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. ohjmd@yuhs.ac
- Publication Type:Case Report
- Keywords:
Minimal change disease;
rifampicin;
steroid
- MeSH:
Aged;
Antibiotics, Antitubercular/*adverse effects/therapeutic use;
Edema/etiology;
Female;
Humans;
Kidney Function Tests;
Kidney Glomerulus/pathology;
Nausea/etiology;
Nephrosis, Lipoid/*chemically induced/pathology;
Proteinuria;
Remission Induction;
Rifampin/*adverse effects/therapeutic use;
Treatment Outcome;
Tuberculosis, Pleural/*drug therapy
- From:Yonsei Medical Journal
2015;56(2):582-585
- CountryRepublic of Korea
- Language:English
-
Abstract:
There are several reports to demonstrate that rifampicin, a major anti-tuberculosis agent, is associated with some adverse renal effects, with a few cases of rifampicin-induced minimal change disease (MCD). In the present case, a 68-year-old female presented with nausea, vomiting, foamy urine, general weakness and edema. She had been taking rifampicin for 4 weeks due to pleural tuberculosis. The patient had no proteinuria before the anti-tuberculosis agents were started, but urine tests upon admission showed heavy proteinuria with a 24-h urinary protein of 9.2 g/day, and serum creatinine, albumin, and total cholesterol levels were 1.36 mg/dL, 2.40 g/dL, and 283 mg/dL, respectively. MCD was diagnosed, and the patient achieved complete remission after cessation of rifampicin without undergoing steroid therapy.
