Study on some factors influencing on the stability of tobramycin 0.3% eye drops
- Author:
Tran Thi Minh Thu
- Publication Type:Journal Article
- Keywords:
Tobramycin 0.3%
- MeSH:
Ophthalmic Solutions;
Tobramycin;
Drug Stability
- From:Pharmaceutical Journal
2005;0(7):19-23
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Study on some influencing factors such as buffer, antioxidant substances to build primary formulation of tobramycin eye drops with stability over 12 months. Result: temperature and light have much influence to the stability of tobramycin and pH contents of eye drops solution. High temperature impacts clearly to the decrease of tobramycin pH and contents. The solution was stable with borate buffer more than phosphate and citrate buffer. Product samples without antioxidant substances have low remained tobramycin contents, about 70% after three months ageing. Dinatri EDTA, natri bisulfit and dinatri EDTA-natri bisulfit combination have significant effect to the stable of tobramycin content. However, dinatri EDTA choice compared with dinatri EDTA-natri bisulfit combination is the same because of dinatri EDTA effect. Dinatri EDTA has better effect to the stable of pH and increase anti-bacteria effect of benzalkonium chloride
