Studies of modifying effects of fullerene on ~(60)Co - γ irradiated zebrafish
10.3760/cma.j.issn.0254-5098.2010.01.002
- VernacularTitle:富勒烯对斑马鱼~(60) Coγ辐射生物效应修饰作用的研究
- Author:
Jin NI
;
Zhigang DAN
;
Fu GAO
;
Ding SUN
;
Jianming CAI
- Publication Type:Journal Article
- Keywords:
Fullerene;
γ-irradiation;
Zebrafish;
Radiomodification
- From:
Chinese Journal of Radiological Medicine and Protection
2010;30(1):5-8
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the modification of C_(60) on the radiation effects of ~(60)Co-γ irradiation on zebrafish.Methods The adult and embryonic zebrafish were used as model organisms to examine the potential of C_(60) to elicit oxidative stress responses on the surviving rate,hatching rate and malformation occurrence,both upon exposure to light or in the dark.Reactive oxygen species (ROS) production and DNA damage were examined as the possible underlying mechanism.Results 500 × 10~(-9) nano-C_(60) waterborne exposure could enhance the γ-irradiation effects by decreasing adult fish survival upon light exposure,which resulted in ROS and DNA damage increasing.The hatching rates were also inhibited with higher malformation,though dark exposure did not make any enhancement,except that the 5000× 10~(-9) C_(60) would inhibit larvae hatching and induced more malformation.Conclusions Waterborne nano-C_(60) exposure may enhance the radiation effects on zebrafish,ROS production and DNA damage increasing may be the underlying mechanism.
