Radiosensitization of nitroindazole derivatives on HeLa cells
10.3760/cma.j.issn.0254-5098.2010.01.005
- VernacularTitle:5-硝基吲唑衍生物对HeLa细胞的放射增敏作用
- Author:
Hao WANG
;
Peiji SHI
;
Xiaoliang ZHOU
;
Yan WANG
;
Weisheng TANG
- Publication Type:Journal Article
- Keywords:
5-Nitroindazole-3-formyliminodiacetic acid;
HeLa cells;
Hypoxia;
Radiosensitization
- From:
Chinese Journal of Radiological Medicine and Protection
2010;30(1):20-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the cytotoxicity and radiosensitization of 5-nitroindazole-3-formyliminodiacetic acid on HeLa cells.Methods HeLa cells in exponential growth phase were incubated in culture media with different doses and the survival rate was determined by MTT assay.The survival rate of cells receiving radiation combined with different doses of medicine was compared with that of the control.Results The cytotoxicity of S-nitroindazole-3-formyliminodiacetic acid on HeLa cells was very low.The drug had hypoxia radiosensitizing effect on HeLa cells.At doses of 0,6,12,24,48 and 96 μg/ml under hypoxia ,the survival rate were 0.91 ,0.87,0.84,0.81 ,0.76 and 0.60,respectively.At the dosage of 48 and 96 μg/ml,the survival rate were 0.85 and 0.73 under oxygenous).Conclusions 5-Nitroindazole-3-formyliminodiacetic acid has low cytotoxicity and rediosensitizing effect on HeLa cells.
