Clinical features of primary Sj(o)gren syndrome complicated with liver damage and its related factors
10.3760/cma.j.issn.1671-7368.2010.04.010
- VernacularTitle:原发性干燥综合征合并肝损伤的临床特点及独立危险因素分析
- Author:
Jing HE
;
Chun LI
;
Lu QIANG
;
Yin SU
;
Zhanguo LI
- Publication Type:Journal Article
- Keywords:
Sj(o)gren's syndrome;
Hepatitis,autoimmune;
Liver cirrhosis,biliary
- From:
Chinese Journal of General Practitioners
2010;9(4):248-251
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study clinical features of liver damage in primary Sj(o)gren syndrome (pSS) and its related factors.Methods One hundred and forty-nine patients of confirmed pSS hospitalized at Peking University People's Hospital were analyzed retrospectively.Results Seventeen of 149 patients of pSS (11.4%) showed liver damage,10 diagnosed as autoimmune hepatitis and seven as primary biliary liver cirrhosis.Increased serum levels of IgG,IgM and γ-globulin accounted for 88.2% and 50.8%,35.3% and 5.3%,and 94.1% and 47.7% of those complicated with and without liver damage,respectively,with statistically significant difference (P ＜ 0.05).Positive serum anti-mitochondria antibody subtype M2 (AMA-M2) was 35.3% in pSS patients with liver damage,significantly higher than that in those without liver damage (1.5%) (P ＜ 0.05).Independent risk factors significantly associated with liver damage included age (OR = 1.013,95% CI 0.971-1.058),course of illness (OR = 1.089,95% CI 1.032-1.150),serum level of γ-globulin (OR = 4.021,95% CI 1.246-12.982),positive AMA-M2 (OR = 11.82,95% CI 0.005-0.157),and positive anti-SSA (OR = 101.333,95% CI 12.653-811.560).Conclusions Liver damage occurred rather high in pSS patients and increased serum levels of IgG,IgM,γ-globulin and anti-SSA can be used to predict their complication with liver damage.Age,course of illness,serum level of γ-globulin,positive AMA-M2 and positive anti-SSA are all significantly associated with liver damage in pSS patients.
