Analysis of plasma soluble human leukocyte antigen-G levels in patients with systemic lupus erythematosus
10.3760/cma.j.issn.1007-7480.2010.05.010
- VernacularTitle:血浆可溶型人类白细胞抗原-G在系统性红斑狼疮患者中的表达分析
- Author:
Fengxia WU
;
Lijun WU
;
Xiongyan LUO
;
Minghui YANG
;
Banjiang KUER
;
Ningtao LIU
;
Xiaoyun SONG
;
Zhong TANG
;
Jingguo ZHOU
;
Guohua YUAN
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,systemic;
HLA antigens
- From:
Chinese Journal of Rheumatology
2010;14(5):323-325
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine plasma soluble HLA-G (sHLA-G) levels in patients with systemic lupus erythematosus (SLE),and to analyze its association with the possibility of organs or systems involvement in lupus patients.Methods Plasma samples were collected from 96 SLE patients and 74 healthy controls,and sHLA-G levels were determined by enzyme-linked immunosorbent assay.The sHLA-G levels in SLE patients and healthy controls were compared with students't-test.The difiefence of clinical and seroimmunological data among the SLE patients was assessed by chi-square test or students't-test.A value of P<0.05 was considered to be significant.Results Plasma concentration of sHLA-G was significanto higher in SLE patients than that in healthy controls[(230±192)U/ml vs(118±38)U/ml,P=0.0001].No relationship between plasma sHLA-G levels and SLE disease activity index(SLEDAI)was found(r=0.157,P=0.141).However,the patients with increased levels of sHLA-G had more severe disease activity (11±5 vs 8±5,P=0.027) and more central nervous system (CNS) involvement (24.2% vs 4.8%,P=0.007) in comparison with patients with normal plasma levels of sHLA-G.Conclusion The increased production sHLA-G,paralleled with more severe disease activity and higher CNS involvement,indicates that sHLA-G may play an important role in the pathogenesis of SLE.
