Correlation of plasma PAC-1 and CD62P levels with diabetic nephropathy in type 2 diabetes mellitus

VernacularTitle:2型糖尿病患者血小板膜糖蛋白PAC-1、CD62P的表达及与糖尿病肾病的相关性研究
Author: Dongying LI ; Xiujun BU ; Hong YANG
Publication Type:Journal Article
Keywords: Diabetic nephropathy; Platelet activating factor
From: Chinese Journal of General Practitioners 2010;09(7):495-497
CountryChina
Language:Chinese
Abstract: Three hundred and thirty eight patients with type 2 diabetes mellitus( DM) admitted from January 2006 to June 2009 and 50 healthy subjects (control group) were enrolled in the study. Platelet glycoprotein PAC-1 and CD62P levels were measured in both groups. Compared with control group, plasma PAC-1 and CD62P levels of DM patients increased significantly (P ＜0.01). Patients were divided into three groups according to their urinary albumin excretion rate ( UAER) . PAC-1 and CD62P levels in macroalbuminuria group (UAER≥200μg/min) were significantly higher than those in normoalbuminuria group( UAER <20μg/min) and microalbuminuria group (20μg/min≤UAER ＜ 200μg/min) (both P＜ 0.05). The results indicate that plasma levels of PAC-1 and CD62P, which reflect platelet activation, are the independent risk factors for diabetic nephropathy.