The effect of mild hypothermia on inflammation status and lung function protection in patients with acute respiratory distress syndrome
10.3760/cma.j.issn.1673-4904.2010.19.008
- VernacularTitle:亚低温治疗急性呼吸窘迫综合征患者对炎性反应影响及肺保护作用的研究
- Author:
Zhao HUANG
;
Sirong WANG
;
Yusheng CHEN
;
Jiyun LIU
- Publication Type:Journal Article
- Keywords:
Respiratory distress syndrome,adult;
Hypothermia;
Cytokines
- From:
Chinese Journal of Postgraduates of Medicine
2010;33(19):21-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of mild hypothermia on inflammation status,lung function protection and clinical prognosis in patients with acute respiratory distress syndrome (ARDS).Methods All of 56 patients with ARDS were randomly divided into two groups: trial group (29 patients,treatment with mild hypothermia) and control group (27 patients, treatment with common practice). The following parameters including tumor necrosis factor (TNF)-α,interleukin (IL)-6 and C reactive protein (CRP), oxygenation index, SOFA evaluation and injury of lungs evaluation were detemined before treatment and at the 3rd, 7th day after treatment, and survival rates and adverse reaction in 28 days also were observed.Results After treatment, the levels of TNF-α ,IL-6 and CRP were decreased significantly, and oxygenation index, the scores of SOFA evaluation and injury of lungs evaluation were improved significantly in trial group than those in control group (P<0.05 ). The survival rate in trial group was higher than that in control group after treatment of 28 days [65.5%(19/29) vs 51.9%(14/27)]. The courses of mechanical ventilation and staying in ICU in trial group were shorter than those in control group [(11.9±3.6)d vs (17.0±5.1)d,(14.1±4.2)d vs (21.5±7.7)d](P<0.05). Conclusion Mild hypothermia can effectively attenuate inflammation disorder, improve damaged lung function and prognosis in patients with ARDS.
