Effects of repeatedly forced swim stress on CNV-like potential in rats
10.3760/cma.j.issn.1674-6554.2010.06.010
- VernacularTitle:慢性强迫游泳应激对实验大鼠类关联负变事件相关电位的影响
- Author:
Dong GAO
;
Mingfei HAN
;
Zhong ZHENG
;
Xiaojiang JIANG
;
Huadong ZHOU
;
Xueli SUN
- Publication Type:Journal Article
- Keywords:
Depression;
Event related potentials;
Contingent negative variation;
Forced swim stress;
Rat
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2010;19(6):507-509
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore whether there were abnormalities of behavioral tests and CNV-like potential in stressed rats following repeatedly forced swim stress.Methods Forty male rats were randomly divided into 4 groups: the control groups (Control-1 and Control-2) and the stress groups ( Stress-1 and Stress-2).Rats in stress groups were administered to repeatedly forced swim 7 or 14 days respectively.Body weight gain, saccharin preference test and open field test were performed.After being anesthetized with urethane, CNV-like potentials were elicited by condition-test stimulus.Results Results of behavioral tests displayed less body weights (F =253.60, P＜0.001 ) and less saccharine solution intake (F= 13.67, P=0.001 ) in stressed group rats and significant effects of stress on the number of crossing squares, the duration of rearing and the number of grooming in open field test.CNV amplitudes were lower in the stressed rats than those in control (F=21.312, P＜0.01 ).Conclusion This study provides an important evidence of changes of CNV-like potential in depressed rats following repeatedly forced swim stress.Based on this study, ER Ps should be taken into consideration and applied as the useful tools in the research work of depressed animal models.
