Na+ ,K+ -ATPase and cerebral ischemia
10.3760/cma.j.issn.1673-4165.2010.005.013
- VernacularTitle:Na+,K+-ATP酶与脑缺血
- Author:
Wenhong PENG
;
En XU
- Publication Type:Journal Article
- Keywords:
Sodium-potassium-exchanging ATPase;
Brain ischemia;
Ischemic preconditioning;
Cardiac glycosides;
Cytidine diphosphate choline
- From:
International Journal of Cerebrovascular Diseases
2010;18(5):381-385
- CountryChina
- Language:Chinese
-
Abstract:
The basic functions of the Na+/K+ -ATPase is to maintain the balance of the Na+/K+ electrochemical gradient. The latter is indispensable for maintaining cell osmotic pressure,regulating cell volume,and maintaining excitable membrane resting potential. The maintenance of the Na+/K+ -ATPase activity plays the important roles in neurotransmitter uptake in neurons and Ca2+ effiux. The decreased Na+/K+ -ATPase activity and dysfunction participate in the process of ischemic brain injury after cerebral ischemia. Ischemic precondi-tioning induces ischemic tolerance by maintaining the Na+/K+ -ATPase activity after ischemia.Cardiotonic steroids and citicoline may play a neuroprotective effect on cerebral ischemia by improving the Na +/K+ -ATPase activity.
