Study on the changes and clinical significance of the DNT cells and T lymphocyte subtype in children with infectious mononucleosis

VernacularTitle:传染性单核细胞增多症患儿CD3+CD4-CD8-T细胞与T淋巴细胞亚群变化情况及临床意义
Author: Huiqin XUE ; Lei ZHU ; Rui ZHAO ; Huimin GUO ; Weili DU
Publication Type:Journal Article
Keywords: Infectious mononucleosis/IM/ME; T-lymphocytes/IM/ME; T-lymphocyte subsets/IM/ME; Antigens,CD3/IM/ME; Antigens,CD4/IM/ME; Antigens,CD8/IM/ME
From: Journal of Chinese Physician 2010;12(6):772-774
CountryChina
Language:Chinese
Abstract: Objective To study on the changes of the DNT cells and T lymphocyte subtype in children with infectious mononucleosis (IM) and its clinical significance.Methods The flow cytometry (FCM) was used to detected the DNT cells and other T lymphocyte subtype in 48 cases of IM.Results The study showed that DNT cells( 9.39 ± 4.89 )% were greatly increased in comparison with normal controls (NC) (4.26 ± 1.68)% ( P ＜0.01 ).CD4 cells(21.45 ±9.87)% were decreased ( P ＜0.01 ) and CD8 cells increased in comparison with NC (32.43 ± 5.07) % ( P ＜ 0.01 ).Conclusion DNT cells and T lymphocyte subtype can be used to evaluate the immune function of children with infectious mononucleosis (IM) and provide guidance for adoptive immunotherapy.