Fatty acid-binding proteins and the early diagnosis of cardio-cerebrovascular diseases
10.3760/cma.j.issn.1673-4165.2010.02.010
- VernacularTitle:脂肪酸结合蛋白与心脑血管病的早期诊断
- Author:
Lijun ZHANG
;
Zhong ZHAO
- Publication Type:Journal Article
- Keywords:
Fatty acid-binding proteins;
Biological markers;
Myocardial infarction;
Brain infarction
- From:
International Journal of Cerebrovascular Diseases
2010;18(2):128-131
- CountryChina
- Language:Chinese
-
Abstract:
Currently, the commonly used diagnostic markers have the shortcomings of lower sensitivity or specificity in the early diagnosis of cardio-cerebrovascular diseases. Therefore, it needs to use the novel specific biochemical markers for the early diagnosis arid treatment, so as to decrease the high mortality and disability caused by cardio-cerebrovascular events. Fatty acid-binding proteins (FABPs) are a family of low-molecular-weight intracellular lipid-binding proteins. They are divided into 9 different subtypes, including the liver-, intestinal-, heart-, brain-, adipocyte-, skin-, ileal-, myelin-, and testis-subtype. Their primary function is to transport long-chain fatty acids into the cells, and thus regulate intracellular lipid metabolism. The structures of all FABP subtypes are similar, inclusive of two α2 helices arid one β2 fold structure. Among them, the sensitivities and specificities of the heart- and brain-subtype FABPs are higher in the early diagnosis of cardio-cerebrovascular diseases. It is promising to become the novel markers in the early diagnosis of cardio-cerebrovascular diseases.
