Effect of total parenteral nutrition or early enteral and parenteral nutrition on immune function in critically ill neurosurgical patients
10.3760/cma.j.issn.1674-635X.2010.03.011
- VernacularTitle:早期全肠外营养及肠内、外混合营养对神经外科危重患者免疫功能的影响
- Author:
Xingru WU
;
Zibin TIAN
;
Liandi LI
;
Xinjuan KONG
;
Liangzhou WEI
;
Cuiping ZHANG
;
Qingxi ZHAO
- Publication Type:Journal Article
- Keywords:
Enteral nutrition;
Immune;
Neurosurgery;
Total parenteral nutrition
- From:
Chinese Journal of Clinical Nutrition
2010;18(3):171-174
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of support with total parenteral nutrition(TPN)or early enteral and parenteral nutrition(EN+PN)on immune function of critically ill neurosurgical patients.Methods In this prospective control study,patients were divided inte TPN group and EN+PN group based on the timing of admission.The changes of immunological indicators including CD3,CD4,CD8,CD4/CD8,CD3/CD25,IgA,IgG,IgM,and serum protein before and after nutritional support were compared.Results The percentage of T lymphocyte subsets CD3,CD4,and CD8,the ratio of CD3+/CD25+,the plasma leveh of IgA,IgM,and IgG,and the serum protein were significantly increased after nutrifional supports(P<0.05,P<0.01).However,compared with the TPN group,the percentages of T lymphocyte subsets(CD3,CD4,and CD8),the ratio of CD4+/CD8+,the plasma levels of IgA,IgM,and IgG,and the serum protein were significantly higher in EN+PN group(P<0.05,P<0.01).Conclusions Both TPN and EN+PN can promote the recovery of immune function,while EN+PN is superior to TPN.Early nutritional support should be provided to critically ill neurosurgical patients.
