Risk factors and anticoagulation parameters in patients of acute exacerbation of chronic obstructive pulmonary disease combined with deep venous thrombosis
10.3760/cma.j.issn.1673-4904.2010.19.001
- VernacularTitle:慢性阻塞性肺疾病急性加重期合并深静脉血栓形成危险因素及抗凝因子检测
- Author:
Jianying SUN
;
Sa LIU
;
Hongyang WANG
;
Chen LIU
;
Xinru LIU
;
Hongguang JIA
- Publication Type:Journal Article
- Keywords:
Pulmonary disease,chronic obstructive;
Venous thrombosis;
Pulmonary embolism;
Blood coagulation
- From:
Chinese Journal of Postgraduates of Medicine
2010;33(19):1-3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the risk factors and anticoagulation parameters in patients of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) combined with deep venous thrombosis (DVT). Methods All of 110 AECOPD patients were divided into two groups according to Doppler examination of lower extremities: DVT group and non-DVT group. The risk factors and anticoagulation parameters were compared. Results Twelve cases (10.9%) were in DVT group,of whom 2 cases (1.8%)had pulmonary embolism. The rate of lying in bed > 3 d, smoke, mechanical ventilation, hospital stays and the levels of PaCO2 were significantly higher in DVT group than those in non-DVT group (P < 0.01 or <0.05 ). In DVT group, the activity of antithrombin Ⅲ and the level of protein S decreased (P < 0.05 ), and the level of D-Dimer increased (P < 0.05). Conclusions Long-term bed, smoke and mechanical ventilation requirement are the main risk factors of DVT in patients with AECOPD. Respiratory failure (type Ⅱ ) is easier to combine with DVT. Abnormality of coagulation and fibrinolytic system exists in AECOPD with DVT.
