Expression of angiopoietin-2 and its relationship with microvessel density in sqnamous carcinoma of esophagus
10.3760/cma.j.issn.1673-4904.2009.02.006
- VernacularTitle:食管鳞癌中血管生成素-2的表达及其与微血管密度的关系
- Author:
Yonglian WANG
;
Baosheng ZHAO
;
Zhongmin WANG
;
Zhijun CHEN
;
Guochong ZHAO
;
Hanchen LI
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms;
Angiopoiedn-2;
Antigens,CD34;
Microvessel density
- From:
Chinese Journal of Postgraduates of Medicine
2009;32(2):14-16
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the expression of angiopoietin-2(Ang-2) in squamous carcinoma of esophagus,and discuss the relationship between Ang-2 and microvessel density(MVD)and clinical pathological features of squamous carcinoma of esophagus.Method The expression of Ang-2 and CD34 in 80 squamous careinoma of esophagus and 25 normal esophagus were detected by immunohistochemistry SABC technique,and the MVD of tissues signed by CD34 was counted.Results The expression of Ang-2 in squamous carcinoma of esophagus was,higher than that in normal esophagus (P<0.05).The expression of Ang-2 in the stage O-I and II squamous carcinoma of esophagus was lower than that in stage Ⅲ and lV(P<0.05).The expression of Ang-2 in squamous carcinoma of esophagus was correlated with differentiation of esophageal carcinoma and lymph node metastasis and infiltrative deepness.There was a remarkable posidve correlation between the expression of Ang-2 and MVD in squamous carcinoma of esophagus (r=0.603,P<0.05). Conclusion The expression of Ang-2 may be elated to the development of squamous carcinoma of esopha- gus,and may promote the development of squamous carcinoma of esophagus by promoting angiogenesis in tumor.
