Expression of angiopoietin-2 and endostatin in human glioma and its significance

VernacularTitle:促血管生成素-2、内皮抑素在人脑胶质瘤中的表达及意义
Author: Yonghan CHEN ; Guojing LI ; Liming REN ; Bo XIAO ; Zibing WEI ; Gang ZHANG ; Junchao YAO ; Linwei JIA
Publication Type:Journal Article
Keywords: Endostatins; Angiopoietin-2; Glioma
From: Chinese Journal of Postgraduates of Medicine 2009;32(2):20-23
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of endostatin and angiopoietin (Ang)-2 in human ghoma and its significance. Methods The expression of endostatin and Ang-2 were measured by immunohistochemistry and endostatin mBNA by hybridization in situ in 108 cases of brain glioma and 5 cases of normal brain tissues. Results The expression of endostatin (0.0657±0.0038)and Ang-2 (0.0286± 0.0042) were significantly higher in grade Ⅲ-Ⅳ glioma patients than those in grade Ⅰ-Ⅱ ghoma patients (0.0349±0.0048,0.0084±0.0018, respectively) and normal brain tissues (0,0)(P<0.01). The expression of endostatin mRNA were significantly higher in grade Ⅲ-Ⅳ glioma patients (0.0310±0.0041) than that in grade Ⅰ-Ⅱ glioma patients (0.0152±0.0031) and normal brain tissues (0)(P< 0.01 ). Theratio of endo-stalin to Ang-2 was negatively rehted to the grade of glioma (r=-0.810,P <0.01). Conclusion The interaction of endostatin and Ang-2 plays an important role in the invasive growth and malignant development of human glioma, and may be related to the prognosis and the malignant degree of glioma.