The detection of interleukin-33 and the correlated research of interleukin-33 and early rheumatoid arthritis
10.3760/cma.j.issn.1007-7480.2010.07.003
- VernacularTitle:白细胞介素-33的测定及其与早期类风湿关节炎相关性的研究
- Author:
Heqing HUANG
;
Rong MU
;
Xia LIU
;
Shiyao WANG
;
Yinong LI
;
Zhanguo LI
- Publication Type:Journal Article
- Keywords:
Arthritis,rheumatoid;
Interleukins;
Autoantibodies
- From:
Chinese Journal of Rheumatology
2010;14(7):446-449
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between serum interleukin (IL)-33 and early rheumatoid arthritis (RA) by testing the serum IL-33 of patients with RA.Methods One hundred patients with early RA whose disease duration was less than 1 year were selected,40 patients with osteoarthritis (OA) and 70 healthy controis were selected.The serum IL-33 levels of the three groups were detected by enzyme-linked immunosorbent assay (ELISA).The correlation between serum IL-33 levels and clinical features of patients with RA were analyzed.Kruskal-Wallis test,Mann-Whitney U test,X2 test and Spearman correlation analysis were used for statistical analysis. Results The level of serum IL-33 in RA patients [(282±871)pg/ml ] was significantlv higher than that of the healthy controls [(7±38) pg/ml,P