The detection of interleukin-33 and the correlated research of interleukin-33 and early rheumatoid arthritis

VernacularTitle:白细胞介素-33的测定及其与早期类风湿关节炎相关性的研究
Author: Heqing HUANG ; Rong MU ; Xia LIU ; Shiyao WANG ; Yinong LI ; Zhanguo LI
Publication Type:Journal Article
Keywords: Arthritis,rheumatoid; Interleukins; Autoantibodies
From: Chinese Journal of Rheumatology 2010;14(7):446-449
CountryChina
Language:Chinese
Abstract: Objective To analyze the correlation between serum interleukin (IL)-33 and early rheumatoid arthritis (RA) by testing the serum IL-33 of patients with RA.Methods One hundred patients with early RA whose disease duration was less than 1 year were selected,40 patients with osteoarthritis (OA) and 70 healthy controis were selected.The serum IL-33 levels of the three groups were detected by enzyme-linked immunosorbent assay (ELISA).The correlation between serum IL-33 levels and clinical features of patients with RA were analyzed.Kruskal-Wallis test,Mann-Whitney U test,X2 test and Spearman correlation analysis were used for statistical analysis. Results The level of serum IL-33 in RA patients [(282±871)pg/ml ] was significantlv higher than that of the healthy controls [(7±38) pg/ml,P