Clinical value of the interleukin-19 level in peripheral blood of patients with bronchial asthma
10.3760/cma.j.issn.1673-4904.2010.10.008
- VernacularTitle:支气管哮喘患者外周血白细胞介素-19的动态变化及其临床意义
- Author:
Shengwei CHEN
- Publication Type:Journal Article
- Keywords:
Asthma;
Interleukin-19;
Immunoglobulin E;
Oxyphil cells
- From:
Chinese Journal of Postgraduates of Medicine
2010;33(10):21-23
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the level of interleukin(IL)-19 in peripheral blood of patients with asthma and investigate its importance.Methods Serum samples were obtained from 45 asthmatic patients (acute attack group and catabasis group) and 45 subjects (control group).The level of IL-19 and IgE in peripheral blood was respectively determined with ELJSA.The accurate number of eosinophile granulocyte (EOS) in peripheral blood was counted with cytoanalyze.Results The levels of IL-19,IgE and the quantity of EOS were (327.92 ± 245.79) ng/L,(260.48 ± 108.77) kU/L,(498.29 ± 96.46) x 107L in acute attack group,(165.54 ± 114.76) ng/L,(164.33 ± 59.08) kU/L,(224.67 ± 86.28) x 106/L in catabasis group,and (49.67 ±40.48) ng/L,(68.12 ± 25.70) kU/L,(31.84 ± 28.27) x 106/L in control group.Compared with control group,the levels of IL-19,IgE and the quantity of EOS in acute attack group and catabasis group were obvious higher than those in control group (P < 0.05).The level of IL-19 and the quantity of EOS in acute attack group were higher than those in catabasis group (P <0.05),but there was no significant difference in the level of IgE between acute attack group and catabasis group (P > 0.05).Furthermore,the results of correlation analysis showed that the level of IL-19 positively correlated with the level of IgE and the quantity of EOS respectively (r = 0.826 >0.738,P< 0.05).Conclusions The ascending degree of the IL-19 level is different during various periods of asthma.It may be inferred that IL-19 can play an important role in the pathogenesis of asthma,and observing the change of the IL-19 level dynamically is useful in diagnosing asthma and monitoring patient's condition.
