Voxel-based morphometry in the Parkinson variant of multiple system atrophy
10.3760/cma.j.issn.1005-1201.2010.07.002
- VernacularTitle:基于体素的形态测量学在震颤麻痹型多系统萎缩中的应用
- Author:
Yanping ZHAO
;
Han WANG
;
Zhuo LI
;
Feng FENG
- Publication Type:Journal Article
- Keywords:
Multiple system atrophy;
Magnetic resonance imaging;
Anthropometry
- From:
Chinese Journal of Radiology
2010;44(7):682-686
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess patterns of the gray and white matter atrophy in patients with multiple system atrophy-P(MSA-P)variant of whole brain compared with normal controls.Methods Three dimensional fast spoiled gradient echo(3D-FSPGR)T1WI of whole brain were obtained from 13 patients with probable MSA-P and 14 age-matched normal controls.The volume of gray matter(GM)and white matter (WM)of MSA-P patients and normal controls was analyzed with voxel-based morphometry(VBM) using statistical parametric mapping(SPM)8.Results Compared with the controls,the MSA-P patients showed decreased gray matter and white matter in bread areas. Gray matter loss mainly symmetrically distributed in bilateral supplementary motor area(SMA),dorsal posterior cingulate cortex(DPCC),medial frontal gyrus,superior temporal gyrus,cerebellum cortex,etc.Unilateral involvement of cortices mainly located in right primary motor cortex.somatosensory association cortex(SAC),and left ventral anterior cingulate cortex (VACC).There Was white matter loss in bilateral superior frontal gyrus,bilateral precuneus,bilateral subgyrus of frontal lobe,left superior temporal gyrus,left cingulate gyrus,right orbitofrontal area,right subgyrus of temporal lobe,etc.Conclusion VBM method is an automatic and comprehensive volumetry method and Can objectively detect the difference of the whole brain structure in patients with probable MSA-P comparing with normal controls.
