Comparison of different effects of electric stimulation of vagus nerve,peripheral nerve,and motor cortex on pentylenetetrazol induced convulsion in rats
10.3760/cma.j.issn.1006-7876.2010.07.004
- VernacularTitle:迷走神经、躯体神经与运动皮质电刺激对戊四氮点燃大鼠惊厥行为的影响
- Author:
Yu SU
;
Yuxi LIU
- Publication Type:Journal Article
- Keywords:
Seizures;
Electric stimulation;
Kindling,neurologic;
Pentylenetetrazole;
Vagus nerve;
Motor cortex
- From:
Chinese Journal of Neurology
2010;43(7):469-472
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether there are different effects of electric stimulation of vagus nerve,peripheral nerve(sciatic nerve and trigeminal nerve),and motor cortex on pentylenetetrazol (PTZ)induced convulsion in rats.Methods The vagus nerve and sciatic nerve were exposed in rats.The stimulation electrodes were placed on the vagus nerve,sciatic nerve,trigeminal nerve,and motor cortex,respectively.After electric stimulation,PTZ(50 mg/kg)was intraperitoneally injected into the rats.The pattern and latency of the convulsion seizure were observed and recorded.Results Racine's grade Ⅰ-Ⅴ grade convulsion seizure Was present in 9 rats(9/10)in the control group after the injection of PTZ.However,this intensity Was reduced to Ⅰ-Ⅲ grade differentially in all the rats by electric stimulation of the vagus nerve(5/10)or peripheral nerve(6/10 and 5/10).Furthermore,in the group of rats stimulated at motor cortex,there Was completely no convulsion.On the other hand,when pathological changes appeared in cortex or hippocampus(i.e.epileptic model was set up by 7 weeks stimulation),the same stimulation of motor cortex was not able to inhibit the convulsion seizure induced by injection of PTZ and all these rats showed Ⅳ-Ⅴ grade seizure(10/10).Conclusions In physiological condition,all of the four types of stimulation differentially reduced intensity of convulsion seizure triggered by PIZ injection and motor cortex stimulation has the best effect.However.when rats were in pathological status and epileptic nidus appeared in their brains.stimulatiion of motor cortex has no effect on PTZ induced convulsion seizure.
