Molecular mechanisms involved in EMT regulated invasion and metastasis of pancreatic cancer
10.3760/cma.j.issn.1673-422X.2010.04.009
- VernacularTitle:上皮细胞间质转型调控胰腺癌侵袭转移的分子机制
- Author:
Guanghui ZHU
;
Zhengjun QIU
- Publication Type:Journal Article
- Keywords:
Epithelial cells;
Stromal cells;
Pancreatic neoplasms;
Neoplasm metastasis
- From:
Journal of International Oncology
2010;37(4):265-269
- CountryChina
- Language:Chinese
-
Abstract:
Loss of epithelial characteristics and acquisition of a mesenchymal phenotype are the main features of epithelial-mesenchymal transition (EMT). EMT plays an important role in tumor invasion and metastasis through increasing cell migration, invasion and anti-apoptotic capacity. Several mechanisms involved in EMT regulate invasion and metastasis of pancreatic cancer,including cadherin switch, growth factors, transcription factors, microRNA and signaling pathways.
