Effect of histone acetylation and deacetylation on bronchial asthma
10.3760/cma.j.issn.1673-4408.2010.04.016
- VernacularTitle:组蛋白乙酰化/去乙酰化在支气管哮喘发病中的作用
- Author:
Lifeng SUN
- Publication Type:Journal Article
- Keywords:
Histone modification;
Epigenetics;
Asthma
- From:
International Journal of Pediatrics
2010;37(4):384-387
- CountryChina
- Language:Chinese
-
Abstract:
The modification of histone is an important mechanism of epigenetics,furthermore histone acetylation and deacetylation is one of the key modifications of histone.There are enhanced expression of histone acetylation and reduced expression and activity of histone deacetylases in asthma,which lead to the unbalance.Glucocoticoids modulate the inflammation of airway in asthma through restoring the balance of the two kinds of enzymes.Theophylline can restore the activity of histone deacetylation in steroid-resistant athma,thereby restoring corticosteroid function.It maybe a new way to find selective histone acetyltransferase inhibitors to therapy asthma.
