A Case of Papillary Thyroid Carcinoma Combined with Multiple Endocrine Neoplasia Type 2A.
- Author:
Ja kyung KIM
1
;
Hae Won CHUNG
;
Hye Sun SEO
;
Dae Jung KIM
;
Sang Su CHUNG
;
Young Duk SONG
;
Kuk Hwan KWON
;
Yoon Mi JIN
;
Mi Kyung LEE
;
Sung Kil LIM
;
Il Jin KIM
;
Hio Chung KANG
;
Jae Hyun PARK
;
Jae Gahb PARK
Author Information
1. Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital, Korea.
- Publication Type:Case Report
- Keywords:
MEN type 2A;
Papillary thyroid carcinoma;
Medullary thyroid carcinoma;
RET oncogene
- MeSH:
Chromosomes, Human, Pair 10;
Codon;
Endoderm;
Germ Layers;
Humans;
Hyperplasia;
Male;
Mass Screening;
Molecular Biology;
Multiple Endocrine Neoplasia Type 2a*;
Multiple Endocrine Neoplasia*;
Neural Plate;
Pheochromocytoma;
Point Mutation;
Proto-Oncogenes;
Thyroid Gland*;
Thyroid Neoplasms*
- From:Journal of Korean Society of Endocrinology
2002;17(5):730-738
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Multiple endocrine neoplasia (MEN) type 2A is a syndrome of medullary thyroid carcinomas, pheochromocytomas and parathyroid hyperplasia. The simultaneous occurrence of medullary, and papillary, thyroid carcinomas is rare because they are derived from, apparently, different germ layers, the former from the neuroectoderm and the latter from the endoderm. We report a case of a papillary thyroid carcinoma, combined with a medullary thyroid carcinoma, in a patient with MEN type 2A. Molecular genetic studies for screening a RET proto-oncogene mutation revealed a point mutation in codon 631 on chromosome 10, which is reported as highly uncommon in MEN type 2A.
