Neurologic complications after liver transplantation in adults
10.3760/cma.j.issn.0254-1785.2010.07.010
- VernacularTitle:肝移植术后早期神经系统并发症的相关因素分析
- Author:
Lai WEI
;
Zhishui CHEN
;
Fanjun ZENG
;
Changsheng MING
;
Dunfeng DU
;
Jiping JIANG
;
Bin LIU
;
Nianqiao GONG
- Publication Type:Journal Article
- Keywords:
liver transplantation;
Postoperative complications;
Nervous system diseases
- From:
Chinese Journal of Organ Transplantation
2010;31(7):418-421
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relevant causes of neurologic complications following liver transplantation.Methods 155 adult patients (131 males, 24 females) who received liver transplantation for the first time at Tongji Hospital between January 2005 and September 2009 were identified.Case notes were reviewed and demographic data, details of the liver disease, neurologic complications, MELD score and discharge information were recorded.Results Neurologic complications occurred following 36 transplants (23.2 %), The complications included mental symptoms in 15 cases (41.7 %), disorder of consciousness and action in 9 cases (25 %), and coma in 12 cases (33.3 %).Twelve percent patients with liver cancer experienced a neurologic complication, which was lower than for other transplant indications, like acute and chronic hepatic failure because of HBV infection (33.3 %, P＜0.01), inborn/metabolic disease (40 %, P＜0.05), and HCV Infection (25 %, P = 0.36).Patients who experienced a neurologic problem had significantly higher MELD score (for non-cancer patients:22.93 ± 8.21; for cancer patients:17 ± 5.4) than the other Patients (for non-cancer patients:18.33 + 8.47, P＜0.05; for cancer patients:13 ±3.4, P＜0.01).The rate of infection (36.1 %) and mortality (30.5 %) were significantly higher in patients with neurologic complications (P＜0.01).The levels of ALT, TBil, ALB, PT and the concentrations of serum sodium and chlorine had no impact on neurologic complications.Conclusion Neurologic complications are common in liver transplant recipients.These complications are related to primary disease and liver function before the operation, and increase the rate of infection and mortality.
