Advance for Diaphanous-related forming
10.3760/cma.j.issn.1673-422X.2010.05.002
- VernacularTitle:Diaphanous相关成蛋白家族的研究
- Author:
Yuanfeng ZENG
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Diaphanous-related formins;
Neoplasm metastasis
- From:
Journal of International Oncology
2010;37(5):327-329
- CountryChina
- Language:Chinese
-
Abstract:
Forming are regulator of actin cytoskeleton. They are characterized with two formin homology domains. Diaphanous-related formin (DRF) is isolated as a subfamily because they have two specific domains such as CBD(GTPase binding domain) and DAD(Diaphanous-autoregulatory domain). DRF is required for a growing number of biological progresses, such as cell adhesion and motility,cytokinesis, morphogenesis, cell polarity and the transcriptional activation of serum response factor. They are closely invovled in cell signal transduction of Rho/Rock, so they play an important role in actin cytoskeleton rearrangements and the process of neoplasm invasion and matastasis. DRF should be studied further, for it will be helpful for deep revealing the mechanism of neoplasm invasion and matastasis, and may be an important basis of potential targets for clinic practice.
