Experimental studies on acute toxicity of Achyranthes Aspera

VernacularTitle:土牛膝的急性毒性实验
Author: Wenjie MA ; Zhifang HUANG ; Zhihong HUANG ; Jilin HU ; Tian WU ; Deliang WEI
Publication Type:Journal Article
Keywords: Local achyranthes aspera; Mice; Acute toxic
From: International Journal of Traditional Chinese Medicine 2010;32(4):349-350
CountryChina
Language:Chinese
Abstract: Objective To observe the acute toxicity of local achyranthes aspera, and its injury to major internal organs. Methods Estimated the dose before the experiment, then selected 40 mice and divided them into five groups randomly, namely 4 dose-groups and one control group. The doses used in the dose-groups were 400 g/kg, 300 g/kg, 225 g/kg and 169 g/kg respectively. Observed the symptoms and the death for successive 7 days and calculated LD (50)with statistic methods. Dissected the dead mice and observed the lesion of organs. Results The LD50 of acute toxicity test of achyranthes aspera was 309.21 g/kg, Sx=0.0359 g/kg. 95% of the limit of trust was 309.14～309.28 g/kg. According to the acute toxic standard, it belonged to non-toxicity. The specimen revealed that large dose administration caused coagulation of blood in both liver and spleen. Conclusion Local achyranthes aspera had little toxicity. Large dose administration affected heart function of mice.