Smac/DIABLO and acute renal ischemia-reperfusion injury
10.3760/cma.j.issn.1673-4408.2010.04.022
- VernacularTitle:Smac/DIABLO与急性肾缺血再灌注性损伤
- Author:
Bing HUA
- Publication Type:Journal Article
- Keywords:
Smac/DIABLO;
Inhibitors of apoptosis protein;
Apoptosis;
Kidney;
Ischemia-reperfusion injury
- From:
International Journal of Pediatrics
2010;37(4):403-405
- CountryChina
- Language:Chinese
-
Abstract:
Ischemia-reperfusion after neonatal asphyxia is a key factor in renal injury,which often leads to apoptosis of tubular epithelial cells.Apoptosis is an important form of injury for renal tubular epithelial cells after asphyxia.Smac/DIABLO is released to the cytosol in response to diverse apoptotic stimuli while mitochondrial targeting signal peptide is removed.In the cytosol,Smac/DIABLO interacts and antagonizes inhibitors of apoptosis proteins,thus allowing the activation of caspases and apoptosis.And thus it increases the ischemia-reperfusion renal injury,leading to acute renal failure.
