Neutrophil elastase and leukemia
10.3760/cma.j.issn.1673-422X.2010.04.022
- VernacularTitle:中性白细胞弹性蛋白酶与白血病
- Author:
Dan ZHU
- Publication Type:Journal Article
- Keywords:
Leukocyte elastase;
Leukemia
- From:
Journal of International Oncology
2010;37(4):306-307
- CountryChina
- Language:Chinese
-
Abstract:
Neutrophil elastase is an important cytotoxicity molecule secreted by neutrophil. It plays a significant role in the development of leukemia. Since this protease can cleave the fusion protein PML-RARα,it may play a role in acute promyelocytic leukemia pathogenesis by facilitating the leukemogenic potential of PML-RARα. Otherwise, this protease might contribute to the clonal dominance of chronic myelognous leukemia by reducing the availability of growth factors for normal hematopoiesis.
