Inhibitor of growth 2 and tumors
10.3760/cma.j.issn.1673-422X.2010.04.002
- VernacularTitle:生长抑制因子2与肿瘤
- Author:
Shasha WANG
;
Yan XIN
;
Yuping XIAO
- Publication Type:Journal Article
- Keywords:
Growth inhibitors;
Apoptosis;
Neoplasms
- From:
Journal of International Oncology
2010;37(4):246-248
- CountryChina
- Language:Chinese
-
Abstract:
Inhibitor of growth 2 (INC2 ) is a member of INC family, and cooperates with p53 in regulating cell cycle, apoptosis, and aging. It can also facilitate chromatin remodeling and transcription regulating through histone modifications. Researches suggest that INC2 protein is an important factor in the genesis, metastasis and prognosis of many kinds of tumors. Resent studies indicate that INC2 can not be simply classified as oncogene or tumor suppressor. At present, the function of INC2 in tumorigenesis and tumor development involves interaction with varied molecules, but the mechanisms remain largely unknown, which still require further investigation.
