Poly(ADP-ribose) polymerase 1 and its inhibitors in tumor treatment
10.3760/cma.j.issn.1673-422X.2010.04.008
- VernacularTitle:聚ADP核糖聚合酶-1及其抑制剂与肿瘤治疗
- Author:
Shuwei CHEN
- Publication Type:Journal Article
- Keywords:
Poly(ADP-ribose) polymerases;
DNA repair enzymes;
Neoplasms;
Poly (ADP-ribose) polymerases inhibitors
- From:
Journal of International Oncology
2010;37(4):263-265
- CountryChina
- Language:Chinese
-
Abstract:
Poly( ADP-ribose) polymerase 1 (PARP-1) plays an essential role in DNA repair and maintenance of homeostasis and genome stability. Increased PARP-1 activity has been reported in various forms of cancer. Thus the absence of PARP-1 or the use of its inhibitors depresses DNA repair function, sensitizes cancer cells to DNA damage and enhances the therapeutic effect of radio-or chemotherapy. PARP-1 is potentially a therapeutic target of malignant tumors.
