Progress in pathogenesis of childhood acute leukemia
10.3760/cma.j.issn.1673-4408.2010.04.011
- VernacularTitle:儿童急性白血病发病机制的研究进展
- Author:
Li ZOU
- Publication Type:Journal Article
- Keywords:
Leukemia;
Fusion genes;
Genetic polymorphism;
Cytokine
- From:
International Journal of Pediatrics
2010;37(4):368-371
- CountryChina
- Language:Chinese
-
Abstract:
Acute leukemia is one of the most common cancers among children.The biological mechanisms leading to leukemia have not been fully clarified until now.Experiments were improved that most patients developing acute leukemia had abnormal chromosomes,including TEL/AML-l,BCR/ABL,PML/RAR-α fusion genes,which would be potential clinical biomarkers.Many genetic polymorphisms have effect on acute lymphoblastic leukemia susceptibility,which were containing genes involved in folate metabolism pathways,cytochrome P450,glutathione-S-transferase enzymes and quinone oxidoreductase-1.As the results of the studies,alcohol,tobacco,TNF-α and IFN-γ might be risk factors to the disease.Furthermore infection and IRF-3 were reported to reduce the occurrence of acute leukemia.Finally,as more is learned about the molecular pathology,it may be possible to develop new therapeutic agents which are specifically targeted to treat childhood acute leukemia.
