Indoleamine 2,3-dioxygenase and immune tolerance in tumor
10.3760/cma.j.issn.1673-422X.2010.04.012
- VernacularTitle:吲哚胺2,3双加氧酶与肿瘤免疫耐受
- Author:
Xiaoqian BU
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Immune tolerance;
Indoleamine-pyrrole 2,3-dioxygenase;
CD4+ CD25+ T cells
- From:
Journal of International Oncology
2010;37(4):276-278
- CountryChina
- Language:Chinese
-
Abstract:
Clonal suppression induced by CD4+ CD25+ regulatory T cells is one of the principal factors to evoke the immune tolerance in tumor. Through the activation of CD4+ CD25+ regulatory T cells, the indoleamine 2,3-dioxygenase (IDO) reduces the immune response in tumor micro-environment of various systems , and induces the formation of host immune tolerance. IDO inhibitor 1-MT is expected to become a new target for cancer treatment.
