The influences of Tangbikang on oxidative stress in rats with diabetic peripheral neuropathy
10.3760/cma.j.issn.1673-4246.2010.04.003
- VernacularTitle:糖痹康对大鼠糖尿病周围神经病变氧化应激影响的实验研究
- Author:
Jia WANG
;
Tonghua LIU
- Publication Type:Journal Article
- Keywords:
Diabetic peripheral neuropathy;
Tangbikang;
Oxidative stress;
Experimental research
- From:
International Journal of Traditional Chinese Medicine
2010;32(4):296-298
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influences of Tangbikang on the oxidative stress in rats with diabetic penipheral neuropathy (DPN). Methods Diabetes rats were induced by intraperitoneal injection of STZ, 55 mg/kg and randomly divided into five groups: model group, methycobal treatment group, and Tang Bi Kang low, medium and high dosage treatment group. Body weight was examined every week. All rats were sacrificed at week 8 and the values of blood serum, superoxide dismutase, malondialdehyde, nitric oxide synthase and nitric oxide were detected. Results After treated with Tang Bi Kang, the eighth week's body weight, the levels of SOD, NOS and NO in the blood serum and ATP of sciatic nerve were increased greatly (P＜0.01 or P＜0.05) and the contents of MDA and AGEs and AR of sciatic nerve were decreased (P＜0.01), compared with the model group. Conclusion Tang Bi Kang may lighten the oxidative stress reaction of diabetic penipheral neuropathy and slow down the course of the diabetic penipheral neuropathy.
