Study on function and mechanism of analgesic effects of herbal medicine extraction on bone cancer pain

VernacularTitle:化瘀止痛法外用对骨癌疼痛模型的镇痛作用及机制研究
Author: Bo DENG ; Liqun JIA ; Fuyun GAO ; Lin PAN
Publication Type:Journal Article
Keywords: Bone cancer pain; Dorsal root ganglion; Herbal medicine extraction for eliminating blood stasis and relieving pain
From: International Journal of Traditional Chinese Medicine 2010;32(4):299-300
CountryChina
Language:Chinese
Abstract: Objective To evaluate the analgesic effects of herbal medicine extraction on bone cancer pain of rat models. Methods Rat models of cancer-induced bone pain was established by using the MRMT-1 cell line injected into the tibia. Changes of behavioral signs indicative of pain including 50% paw withdrawal threshold (von Frey tactile sensitivity test)and thermal withdrawal latency were observed. The cellular reorganization of dorsal root ganglion (DRG) was measured by histological analysis. Results In the behavioural tests, herbal medicine treatment attenuated mechanical allodynia and thermal hyperalgesia. Histological examination showed that herbal medicine inhibited DRG neuronal nuclear and somatic size reduction with nucleolar segregation. Conclusion The herbal medicine extraction was an anti-nociceptive agent in rat models of bone cancer pain.