Experimental study on the mechanism of GuiJi cream in dispelling effects on corrupt microorganism

VernacularTitle:瑰及乳膏祛腐生肌作用机理的实验研究
Author: Zhengping MEI ; Junjie WANG ; Gang WANG ; Mingquan CHANG ; Guangyi YANG
Publication Type:Journal Article
Keywords: Dispelling effects on corrupt microorganism; GuiJi cream; Matrix metalloproteinase; Collagen type Ⅰ
From: International Journal of Traditional Chinese Medicine 2010;32(4):301-302
CountryChina
Language:Chinese
Abstract: Objective To study the mechanism of GuiJi cream in dispelling effects on corrupt microorganism.Methods A total of 90 full-layer skin injured rats were served as test model. The effects of Guiji cream on collagen type Ⅰ (C Ⅰ), matrix metalloproteinase-1 (MMP-1) and MMP-3 in granulation tissue of wound were observed with immunohistochemistry technique and image-analysis system at various stages of healing. Results The expression of C Ⅰ was obviously increased and the level of MMP-1 and MMP-3 increased at the early stage and kept at a high level from day 3 to day 10. Conclusion The mechanism of GuiJi cream for dispelling effects on corrupt microorganism was increasing the C Ⅰ content in granulation tissue of wound through inhibiting the secretion of MMP- 1.